Full Project – Effects Of Vitamin Supplementation On Lead Toxicity In Wistar Albino Rats

Click here to Get this Complete Project Chapter 1-5

Effects Of Vitamin Supplementation On Lead Toxicity In Wistar Albino Rats

ABSTRACT

Oxidative stress is one of the mechanisms involved in lead poisoning. Air Max 2016 Heren Goedkoop Goedkope Nike Air Max schonenen  The present study investigated the role of ascorbic acid, thiamine, pyridoxine, tocopherol, individually and in cocktail in mitigating the biochemical alterations induced by subchronic administration of 500mg/kg of lead acetate for 6 weeks. Air Max 2015 Zwwart Rood Goedkoop Thirty – five wistar albino rats divided into seven groups of five animals in each group were used for this study. Nike Free 5.0 V4 Goedkoop nike air max 1 pas cher. All the animals were fed ad libitum. The first group which served as the negative control received no treatment. Nike REE 3.0 V4 Goedkoop asics tiger pas cher. The second group which served as the positive control had 500mg of lead acetate added per kg of feed. Nike Air Max Thea Print Dame authentique. All other groups received same regimen as the second group but in addition, four other groups received 300mg/kg diet of pyridoxine, thiamine, ascorbic acid and tocopherol respectively, while the last group received 300mg of vitamin mixture containing 75mg each of thiamine, pyridoxine, ascorbic acid and tocopherol per kg of diet. Lunettes de soleil Ray Ban, The rats were sacrificed after 6 weeks and sera obtained from the blood samples were analysed for alanine transaminase(ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities. Nike FS Lite Run Goedkoop Urea and creatinine concentrations were also evaluated. The results indicated that exposure of the animals to lead resulted in a significant increase (p<0.05) in ALT, AST and ALP activities as well as in urea and creatinine concentrations in the positive control group (121.10 ± 4.27 U/L, 180.80 ± 4.26U/L , 227.93 ± 11.14U/L; 62.20 ± 3.29mg/dl and 1.64 ± 0.16mg/dl respectively) when compared with the negative control group ( 75.17 ± 1.39U/L, 126.16 ± 9.13U/L, 146.47 ± 10.04U/L, 35.43 ± 3.18mg/dl and 1.08 ± 0.05mg/dl respectively), indicating damage in the liver and kidney cell membranes. The activities of ALT, AST and ALP as well as the levels of urea and creatinine were significantly lower (p<0.05) in the cocktail treated group (90.67 ± 2.67U/L, 128.68 ± 2.20U/L, 154.43 ± 2.16U/L, 35.72 ± 1.67mg/dl and 1.10 ± 0.04mg/dl respectively), pyridoxine treated group (91.81 ± 2.97U/L, 146.29 ± 3.26U/L, 174.19 ± 12.18U/L, 45.56 ± 4.6mg/dl and 1.25 ± 0.03mg/dl respectively) and all other groups that received vitamin supplementation when compared with the positive control. This indicates that thiamine, pyridoxine, ascorbic acid-tocopherolandhave αameliorative effect on lead induced toxicity on liver and kidney of wistar albino rats. The results also showed that the cocktail group had all the biochemical parameters most significantly lowered suggesting a greater potency in lead toxicity amelioration.

Get the Complete Project

This is a premium project material and the complete research project plus questionnaires and references can be gotten at an affordable rate of N3,000 for Nigerian clients and $8 for International clients.

Click here to Get this Complete Project Chapter 1-5

You can also check other Research Project here:

1. Accounting Research Project
2. Adult Education
3. Agricultural Science
4. Banking & Finance
5. Biblical Theology & CRS
6. Biblical Theology and CRS
7. Biology Education
8. Business Administration
9. Computer Engineering Project
10. Computer Science 2
11. Criminology Research Project
12. Early Childhood Education
13. Economic Education
14. Education Research Project
15. Educational Administration and Planning Research Project
16. English
17. English Education
18. Entrepreneurship
19. Environmental Sciences Research Project
20. Guidance and Counselling Research Project
21. History Education
22. Human Kinetics and Health Education
23. Management
24. Maritime and Transportation
25. Marketing
26. Marketing Research Project 2
27. Mass Communication
28. Mathematics Education
29. Medical Biochemistry Project
30. Organizational Behaviour

32    Other Projects pdf doc

33. Political Science
34. Psychology
35. Public Administration
36. Public Health Research Project
37. More Research Project
38. Transportation Management
39. Nursing

Education

Full Project – Effects Of Vitamin Supplementation On Lead Toxicity In Wistar Albino Rats